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(A). Part I of model showing the recruitment of AGO to a miRNA following interaction with FMRP (B). Part II of model showing fate of Dicer1 mRNA bound by MOV10 and FMRP. Binding of both FMRP and MOV10 in proximity of MRE blocks association with AGO2 [12]. In the absence of MOV10 and FMRP, AGO2 is free to bind the MRE and translational regulation takes place. Pink line indicates MRE.
