Table 1. Anthropometric and Clinical Parameters of the Subjects of the Study^a.

							adjusted p-value
	non-OB IS	non-OB IR	OB IS	OB IR	OB	IR	OB × IR	OB IS versus OB IR	non-OB IR versus OB IR	non-OB IS versus non-OB IR
gender	M = 7, F = 18	M = 3, F = 7	M = 3, F = 8	M = 14, F = 11	n.s.	n.s.	n.s.	n.s.	n.s.	n.s.
age [years]	47.56 ± 13.66	54.90 ± 13.62	40.36 ± 10.64	42.84 ± 8.99	0.004	n.s.	n.s.	n.s.	0.003	n.s.
weight [kg]	64.56 ± 8.64	66.10 ± 5.63	125.97 ± 15.00	154.80 ± 31.20	5.92 × 10–24	0.040	n.s.	n.s.	1.08 × 10–8	n.s.
BMI [kg/cm2]	23.75 ± 2.12	25.30 ± 1.64	46.14 ± 4.58	53.63 ± 9.05	5.38 × 10–26	0.009	n.s.	n.s.	1.08 × 10–8	n.s.
waist [cm]	81.88 ± 7.93	92.70 ± 3.65	128.00 ± 16.18	146.62 ± 21.73	1.69 × 10–18	0.004	n.s.	n.s.	2.34 × 10–6	0.038
hip [cm]	94.88 ± 8.26	101.30 ± 3.66	142.40 ± 11.07	151.25 ± 17.80	1.78 × 10–18	0.031	n.s.	n.s.	2.78 × 10–6	n.s.
waist/hip [ratio]	0.81 ± 0.04	0.90 ± 0.67	0.87 ± 0.11	0.97 ± 0.11	n.s.	n.s.	n.s.	n.s.	n.s.	n.s.
fasting glucose [mmol/L]	89.96 ± 7.59	115.50 ± 14.93	88.82 ± 4.58	115.68 ± 11.63	n.s.	2.67 × 10–13	n.s.	1.15 × 10–7	n.s.	4.34 × 10–5
fasting insulin [μU/mL]	5.33 ± 2.04	12.36 ± 4.04	8.19 ± 2.16	24.81 ± 13.25	0.003	1.03 × 10–10	n.s.	2.89 × 10–6	n.s.	9.13 × 10–4
HbA1c [%] (mmol/mol)	5.32 ± 0.40 (34.59 ± 4.36)	6.14 ± 0.61 (43.59 ± 9.24)	5.63 ± 0.10 (37.96 ± 1.05)	5.69 ± 0.47 (38.68 ±5.11)	n.s.	n.s.	n.s.	n.s.	n.s.	0.002
HOMA-IR [index]	1.18 ± 0.47	3.46 ± 0.99	1.80 ± 0.51	7.10 ± 3.81	0.004	5.75 × 10–14	n.s.	1.15 × 10–7	n.s.	4.34 × 10–5
systolic pressure [mm Hg]	115.42 ± 13.39	133.70 ± 27.61	131.50 ± 22.55	135.61 ± 18.38	n.s.	n.s.	n.s.	n.s.	n.s.	n.s.
diastolic pressure [mm Hg]	71.88 ± 11.54	79.20 ± 8.61	82.00 ± 10.73	84.33 ± 13.43	n.s.	n.s.	n.s.	n.s.	n.s.	n.s.
total cholesterol [mmol/L]	179.20 ± 25.26	241.60 ± 42.61	190.18 ± 50.15	201.76 ± 34.53	n.s.	0.003	n.s.	n.s.	n.s.	0.004
HDL [mmol/L]	55.80 ± 10.59	55.60 ± 17.61	45.73 ± 15.43	39.92 ± 12.95	0.022	n.s.	n.s.	n.s.	n.s.	n.s.
LDL [mmol/L]	105.74 ± 24.40	153.04 ± 41.62	107.51 ± 45.71	134.50 ± 28.57	n.s.	8.28 × 10–4	n.s.	n.s.	n.s.	0.018
triglycerides [mmol/L]	82.36 ± 39.52	166.00 ± 78.62	121.64 ± 112.87	144.47 ± 48.28	n.s.	0.003	n.s.	n.s.	n.s.	0.010
C-reactive protein [mg/L]	2.98 ± 0.77	5.95 ± 2.62	13.80 ± 12.51	8.87 ± 6.24	n.s.	n.s.	n.s.	n.s.	n.s.	0.010
GOT [U/L]	14.60 ± 6.24	14.60 ± 9.62	21.91 ± 8.87	24.64 ± 11.84	1.96 × 10–4	n.s.	n.s.	n.s.	0.018	n.s.
GPT [U/L]	27.48 ± 9.29	32.50 ± 14.62	38.91 ± 16.49	54.20 ± 19.26	2.32 × 10–4	n.s.	n.s.	n.s.	0.018	n.s.
GGT [U/L]	23.64 ± 14.86	37.35 ± 47.62	26.27 ± 17.86	53.88 ± 50.74	0.006	n.s.	n.s.	n.s.	0.003	n.s.
uric acid [mmol/L]	3.74 ± 0.84	4.76 ± 1.62	5.04 ± 0.78	6.49 ± 1.46	6.01 × 10–5	0.003	n.s.	n.s.	n.s.	0.045
creatinine [mmol/L]	0.77 ± 0.20	0.77 ± 0.62	0.74 ± 0.17	0.84 ± 0.18	n.s.	n.s.	n.s.	n.s.	n.s.	n.s.
urea [mg/dL]	30.05 ± 7.95	35.00 ± 7.62	27.90 ± 7.82	32.68 ± 12.13	n.s.	n.s.	n.s.	n.s.	n.s.	n.s.

^aValues are shown as mean ± SD unless otherwise indicated. p-Values were calculated using the ANOVA model and t-test after log-transformed variables were appropriated and corrected by the false discovery rate. Abbreviations: BMI, body mass index; LDL, low-density lipoproteins cholesterol; HDL, high-density lipoproteins cholesterol; GOT, aspartate transaminase; GPT, alanine transaminase; GGT, γ-glutamyl transferase; F, female; HbA1c, glycated hemoglobin A1c; HOMA-IR, insulin resistance calculated by homeostatic model assessment; IR, high insulin resistance; IS, insulin sensitivity; M, male; n.s., not significant; OB, obesity; SD, standard deviation.