Table 2. ROC Curve Parameters of the Combined Multimetabolite Biomarker Model for Detecting Subjects with Obesity and IS and of the Individual Metabolites That Are Part of This Modela.
| detection of OB IS | sensitivity (%) | specificity (%) | AUC (95% CI) |
|---|---|---|---|
| Only in Obese Population | |||
| combined multimetabolite model | 88.0 | 100 | 96.7 (91.9–100) |
| GPE 18:2 | 76.0 | 90.9 | 89.1 (78.8–99.4) |
| GPI 18:0 | 76.0 | 81.8 | 77.5 (56.7–98.2) |
| GPS 18:0 | 84.0 | 72.7 | 78.8 (61.1–96.8) |
| GPC aa 18:0/18:1 (GPC aa 36:1) | 88.0 | 63.6 | 79.3 (61.0–97.6) |
| GPC aa 18:2/18:2 (GPC aa 36:4) | 72.0 | 72.7 | 69.5 (48.7–90.2) |
| GPC aa 18:2/18:3 (GPC aa 36:5) | 72.0 | 72.7 | 71.6 (50.0–93.3) |
| In the Whole Study Population | |||
| combined multimetabolite model | 90.9 | 76.7 | 87.6 (79.0–96.2) |
| GPE 18:2 | 63.6 | 66.7 | 71.8 (56.5–87.2) |
| GPI 18:0 | 81.8 | 66.7 | 70.2 (50.3–90.0) |
| GPS 18:0 | 72.7 | 81.7 | 77.9 (61.9–93.9) |
| GPC aa 18:0/18:1 (GPC aa 36:1) | 63.6 | 66.7 | 61.4 (43.3–79.5) |
| GPC aa 18:2/18:2 (GPC aa 36:4) | 72.7 | 55.0 | 53.0 (35.1–70.9) |
| GPC aa 18:2/18:3 (GPC aa 36:5) | 72.7 | 53.3 | 60.3 (39.1–81.5) |
a
Their predictive power was evaluated in the whole obese subset and in the whole study population including nonobese individuals. Metabolites are sorted alphabetically. Abbreviations: aa, diacyl; AUC, area under the curve; CI, confidence interval; GPC, glycerophosphatidylcholine; GPE, glycerophosphatidylethanolamine; GPI, glycerophosphatidylinositol; GPS, glycerophosphatidylserine.