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. 2021 Nov 11;8:754499. doi: 10.3389/fcvm.2021.754499

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Copyright © 2021 Pascual-Figal, Bayés-Genis, Beltrán-Troncoso, Caravaca-Pérez, Conde-Martel, Crespo-Leiro, Delgado, Díez, Formiga and Manito.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summary of mechanisms of sacubitril/valsartan enhancement of ventricular remodeling. AO, aorta; LA, left atrium; LV, left ventricle; MI, mitral insufficiency; cGMP, cyclic guanosine monophosphate; NO, nitric oxide; sST2, soluble suppression of tumorigenesis-2; Nt-proBNP, N-terminal pro-brain natriuretic peptide; SBP, systolic blood pressure; AMI, acute myocardial infarction; MMP-9, matrix metallopeptidase 9; TIMP-1, tissue inhibitor of metalloproteinase-1; PINP, aminoterminal propeptide of type I collagen.