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. 2021 Nov 11;12:721819. doi: 10.3389/fphar.2021.721819

TABLE 3.

Trough concentrations for common and tailored doses simulated for patients with different levels of creatinine clearance.

CRCL Same dose (mg) Simulated trough conc. (mg/L) Mean ± S.D Tailored dose (mg) Simulated trough conc. (mg/L) Mean ± S.D
20 ml/min 1,000 33.3 ± 7.54 a 400 13.3 ± 3.01
60 ml/min 1,000 23.9 ± 5.73 a 600 14.4 ± 3.44
100 ml/min 1,000 18.0 ± 4.56 800 14.4 ± 3.65
140 ml/min 1,000 13.7 ± 3.79 1,000 13.7 ± 3.79
a

Above target trough concentration range (10–20 mg/l).