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. 2021 Nov 11;12:760988. doi: 10.3389/fphar.2021.760988

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Copyright © 2021 Song, Ma, Hu, Zhao, Bai, Wang, Liu, Li, Sheng, Xu, Zhang and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protocol of CRD-rat model and inflammatory response in rats after OA and CRD modeling. (A) Protocol of CRD-rat model and the control group. (B) Alterations of body weight gain of rats in different groups. Results are expressed as mean ± SD; n = 4–6. ^** p < 0.01 between the shift and non-shift group. (C) Levels of IL-1β, TNF-α, IL-6, iNOS, COX-2, and PGE2 in rat serum in different groups. Results are expressed as mean ± SD; n = 4–6. ^* p < 0.05, ^** p < 0.01, ^*** p < 0.001 and ^**** p < 0.0001.