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. 2021 Nov 11;12:760988. doi: 10.3389/fphar.2021.760988

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Copyright © 2021 Song, Ma, Hu, Zhao, Bai, Wang, Liu, Li, Sheng, Xu, Zhang and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cartilage matrix degradation and inflammation response in chondrocytes after stimulating with IL-1β, transfecting with siBMAL1 and suppressing β-catenin pathway. (A) Protein expression and mRNA level changes of MMP-3 and MMP-13 in chondrocytes in each group. (B) Protein expression and mRNA levels changes of ADAMTS-4 and COX-2 in chondrocytes in each group. (C) Levels of COMP and CTX-Ⅱ in ECS. (D) mRNA level changes of COL2A1 and Aggrecan in chondrocytes in different groups. (E) Levels of TNF-α, IL-6, and PGE2 in ECS. All experiments were performed in triplicate, and the results are expressed as the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.