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. Author manuscript; available in PMC: 2021 Nov 30.
Published in final edited form as: J Med Chem. 2021 Aug 20;64(17):12506–12524. doi: 10.1021/acs.jmedchem.1c00163

Figure 1. Structures of triazolurea (1) and phenylhexanamide (2) mitofusin activators.

Figure 1.

A. Both classes of mitofusin activator share a substituted cyclohexyl (R1, R1’) linked to an aromatic moiety (R2, R2’) by a six or seven member alkyl linker. B. Dose-response relationships for mitochondrial elongation (measured as the increase in mitochondrial aspect ratio) of 2 and its analogs having one (3) or two (4) fewer carbons in the alkyl linker.