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. Author manuscript; available in PMC: 2021 Nov 30.
Published in final edited form as: J Med Chem. 2021 Aug 20;64(17):12506–12524. doi: 10.1021/acs.jmedchem.1c00163

Figure 3. Synthesis of 5 results in a ~50:50 mixture of 5 trans- stereoisomers.

Figure 3.

Left, structures of the four possible 5 stereoisomers. Right, chiral separation identifies two forms, shown to be trans- based on 1H-NMR of synthetic intermediate 5C (Figure S2).