Skip to main content
. Author manuscript; available in PMC: 2021 Nov 30.
Published in final edited form as: J Med Chem. 2021 Aug 20;64(17):12506–12524. doi: 10.1021/acs.jmedchem.1c00163

Figure 5. MFN2 altering activity of 5 is stereoisomer-specific.

Figure 5.

Results of FRET studies comparing MFN2 conformation altering activities of prototype mitofusin activators 1 and 2 with 5 stereoisomers (all compounds added to a final concentration of 1μM as in Figure 4B; assays were performed after 4 hours). Decreased FRET signal reflects MFN2 unfolding as depicted to the right. Blue sun indicates position of amino terminal mCerulean; red sun is C-terminal mVenus. Means ± SEM of 6 separate studies with 4-6 replicates each.