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. Author manuscript; available in PMC: 2021 Nov 30.
Published in final edited form as: J Med Chem. 2021 Aug 20;64(17):12506–12524. doi: 10.1021/acs.jmedchem.1c00163

Figure 6. Mitochondrial fusogenic activities of 5 sulfide analogs.

Figure 6.

A. Structures of 5 sulfide analogs synthesized for X-ray diffraction studies. B. Dose-response curves showing 14B (slower eluting isoform: EC50 = 1.82 nM; 95% confidence limits, 1.04-2.99 nM) and 14A (faster eluting isoform: EC50 = 128.1 nM; 95% confidence limits, 141.94~ nM) increasing mitochondrial aspect ratio (length/width) in cultured fibroblasts lacking Mfn2. Data are means ± SEM from three independent experiments. 1 dose-response is shown for comparison (EC50 = 2.63 nM; 95% confidence limits, 1.45-4.64 nM).