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. Author manuscript; available in PMC: 2021 Nov 30.
Published in final edited form as: J Med Chem. 2021 Aug 20;64(17):12506–12524. doi: 10.1021/acs.jmedchem.1c00163

Table 1.

Functional and pharmacokinetic properties of cycloalkyl linker 2 variants a.

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a

Linker modifications of 2 are shown to the left; functional and PK characteristics are to the right. R1’ is cyclohexanol and R2’ is phenyl as in Figure 1. EC50 95% confidence limits are shown in Figure S1.