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. Author manuscript; available in PMC: 2021 Nov 30.
Published in final edited form as: J Med Chem. 2021 Aug 20;64(17):12506–12524. doi: 10.1021/acs.jmedchem.1c00163

Table 2.

In vivo pharmacokinetic properties of 5 a.

5 2
Dose (mg/kg) 10 10
C0 (ng/mL) 32111 50,600
t1/2 (hours) 1.64 1.1
AUC0-last (ng*h/mL) 9178 11495
Vdss (L/kg) 0.6 0.347
a

IV administration in mice, 10 mg/kg; values for 2 are from (16).