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. 2021 Nov 11;8:774630. doi: 10.3389/fvets.2021.774630

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Copyright © 2021 Hu, Peng, Li, Zhang, Li, Wang, Gu, Hu, Hu, Liu, Jiao, Peng and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The bivalent H5+H7 VLP vaccine stimulates strong IgG antibody. Chickens were i.m. immunized with 15 μg of the bivalent H5+H7 VLP or 0.3 mL of the commercial trivalent (H5: Re-11; H5: Re-12; H7: Re-3) vaccine. The IgG antibody at Week 3 p.v. was determined by ELISA. (A) IgG antibody using purified HA protein of the TT3 virus as coated antigen. (B) IgG antibody using purified HA protein of the A/Chicken/Anhui/AH13/2013 (AH13) virus as coated antigen. (C) Area under the curve (AUC) of the IgG antibody using purified HA protein of the TT3 virus as coated antigen. (D) AUC of the IgG antibody using purified HA protein of the AH13 virus as coated antigen.