Table 2. Comparison of diagnostic sensitivity and specificity of the RBD-ELISA and VNT in a study of SARS-CoV-2 seroprevalence among domestic cats during the first pandemic wave, Europe, April–August 2020*.
Test results | Value |
---|---|
RBD-ELISA sensitivity, % (95% CI) | 90.6 (90.0–91.2) |
RBD-ELISA specificity, % (95% CI) | 99.8 (99.8–99.8) |
No. positive (%; 95% CI), n = 2,160 | |
RBD-ELISA and VNT | 87 (4.0; 3.2–4.9) |
RBD-ELISA only | 92 (4.3; 3.5–5.2) |
VNT only | 96 (4.4; 3.6–5.4) |
*A total of 5 samples were positive with RBD-ELISA and negative with VNT; 9 samples were positive with VNT but negative with RBD-ELISA. RBD-ELISA, receptor-binding domain–specific ELISA; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; VNT, virus neutralization test.