COVID-19 diagnoses, asymptomatic and variant frequency, and lethality, Paraná state, Brazil. A) COVID-19 diagnoses in Paraná and Federal University of Paraná (Curitiba, Brazil) mass testing program positivity rates by epidemiologic week. Blue bars summarize positive cases in Paraná by diagnosis day notified to state surveillance system through February 15, 2021. Red dots represent the fraction of positive cases in all samples from mass screening collection at Federal University of Paraná, smoothed by locally estimated scatterplot smoothing in the red line; pink shading indicates SE from locally estimated scatterplot smoothing fit. B) Overall lethality of COVID-19 in Paraná (purple line) and variant prevalence among asymptomatic and mildly symptomatic cases, by epidemiologic week. Numbers represent the absolute quantity of cases for each variant. Scales for the y-axes differ substantially to underscore patterns but do not permit direct comparisons. COVID-19, coronavirus disease; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.