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. 2021 Nov 11;9:781867. doi: 10.3389/fcell.2021.781867

FIGURE 6.

FIGURE 6

let7f/Periostin/PI3K signaling pathway mediates LINC00106 promoted HCC stemness and metastasis properties. (A–D), Expression of periostin (A), Sphere formation capacities (B), invasion and migration assays (C) and expression of stemness biomarkers (D) in MHCC-97H cells co-transfected with let7f inhibitors or let7f inhibitors NC and sh-LINC00106 or sh-LINC00106 NC; (E–H). Expression of periostin (E), Sphere formation capacities (F), invasion and migration assays (G) and expression of stemness biomarkers (H) in Huh7 cells co-transfected with periostin NC or periostin-vec and sh-LINC00106 or sh-LINC00106 NC; (I,J). Expression of periostin, total and phosphorylated PI3K/AKT3 following co-transfected with periostin-vec and sh-LINC00106 or LINC00106 mimics in HCC cell lines (**p < 0.01).