Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Nov 11;12:761209. doi: 10.3389/fimmu.2021.761209

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Luo, Xue, Tang, Lin, Song, Liu, Yin, Huang, Wei, Mao, Wang and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The performance of various indicators in distinguishing ATB patients from LTBI individuals in Caidian cohort. (A) Scatter dot plots showing the results of the expression of HLA-DR on IFN-γ⁺TNF-α⁺ cells in ATB patients and LTBI individuals. Horizontal lines indicate the medians. ***P < 0.001 (Mann-Whitney U test). (B) ROC curve analysis showing the performance of HLA-DR on IFN-γ⁺TNF-α⁺ cells in discriminating ATB patients from LTBI individuals. (C) Scatter dot plots showing the results of TBAg/PHA ratio in ATB patients and LTBI individuals. Horizontal lines indicate the medians. ***P < 0.001 (Mann-Whitney U test). (D) ROC curve analysis showing the performance of TBAg/PHA ratio in discriminating ATB patients from LTBI individuals. (E) Venn diagrams showing the overlap of HLA-DR on IFN-γ⁺TNF-α⁺ cells and TBAg/PHA ratio in ATB patients. (F) Venn diagrams showing the overlap of HLA-DR on IFN-γ⁺TNF-α⁺ cells and TBAg/PHA ratio in LTBI individuals. (G) Scatter plots showing the predictive value of diagnostic model in ATB patients and LTBI individuals. Horizontal lines indicate the medians. ***P < 0.001 (Mann-Whitney U test). (H) ROC curve analysis showing the performance of diagnostic model based on the combination of HLA-DR on MTB-specific cells and TBAg/PHA ratio in discriminating ATB patients from LTBI individuals. MTB, Mycobacterium tuberculosis; ATB, active tuberculosis; LTBI, latent tuberculosis infection; TBAg, tuberculosis antigens; PHA, phytohemagglutinin; AUC, area under the curve.