Table 2.
The performance of various indicators for discriminating ATB from LTBI in Qiaokou cohort.
| Variables | Cutoff value | AUC (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | PLR (95% CI) | NLR (95% CI) | Accuracy |
|---|---|---|---|---|---|---|---|---|---|
| HLA-DR on IFN-γ+TNF-α+ cells (%) | 49 | 0.886 (0.826-0.946) | 90.00% (78.64%-95.65%) | 61.82% (48.61%-73.48%) | 68.18% (56.21%-78.15%) | 87.18% (73.3%-94.4%) | 2.36 (1.66-3.34) | 0.16 (0.07-0.38) | 75.24% |
| TBAg/PHA ratio | 0.3 | 0.736 (0.645-0.827) | 40.74% (28.68%-54.03%) | 91.94% (82.47%-96.51%) | 81.48% (63.30%-91.82%) | 64.04% (53.69%-73.24%) | 5.05 (2.05-12.42) | 0.64 (0.51-0.81) | 68.10% |
| Diagnostic model | 0.36 | 0.937 (0.892-0.982) | 92.00% (81.16%-96.85%) | 81.82% (69.67%-89.81%) | 82.14% (70.16%-90.00%) | 91.84% (80.81%-96.78%) | 5.06 (2.87-8.92) | 0.1 (0.04-0.25) | 86.67% |
ATB, active tuberculosis; LTBI, latent tuberculosis infection; TBAg, tuberculosis-specific antigen; PHA, phytohaemagglutinin; AUC, area under the curve; PPV, positive predictive value; NPV, negative predictive value; PLR, positive likelihood ratio; NLR, negative likelihood ratio; CI, confidence interval.