Table 3.
The performance of various indicators for discriminating ATB from LTBI in Caidian cohort.
| Variables | Cutoff value | AUC (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | PLR (95% CI) | NLR (95% CI) | Accuracy |
|---|---|---|---|---|---|---|---|---|---|
| HLA-DR on IFN-γ+TNF-α+ cells (%) | 49 | 0.917 (0.856-0.977) | 91.89% (78.70%-97.21%) | 63.89% (47.58%-77.53%) | 72.34% (58.24%-83.06%) | 88.46% (71.03%-96.00%) | 2.54 (1.63-3.97) | 0.13 (0.04-0.39) | 78.08% |
| TBAg/PHA ratio | 0.3 | 0.714 (0.605-0.824) | 37.21% (24.38%-52.14%) | 87.80% (74.46%-94.68%) | 76.19% (54.91%-89.37%) | 57.14% (44.86%-68.60%) | 3.05 (1.23-7.57) | 0.72 (0.55-0.92) | 61.90% |
| Diagnostic model | 0.36 | 0.941 (0.893-0.989) | 91.89% (78.70%-97.21%) | 86.11% (71.34%-93.92%) | 87.18% (73.30%-94.40%) | 91.18% (77.04%-96.95%) | 6.62 (2.92-15.01) | 0.09 (0.03-0.28) | 89.04% |
ATB, active tuberculosis; LTBI, latent tuberculosis infection; TBAg, tuberculosis-specific antigen; PHA, phytohaemagglutinin; AUC, area under the curve; PPV, positive predictive value; NPV, negative predictive value; PLR, positive likelihood ratio; NLR, negative likelihood ratio; CI, confidence interval.