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. 2021 Nov 11;8:779073. doi: 10.3389/fcvm.2021.779073

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Copyright © 2021 Ercan, Schrottmaier, Pirabe, Schmuckenschlager, Pereyra, Santol, Pawelka, Traugott, Schörgenhofer, Seitz, Karolyi, Yang, Jilma, Zoufaly, Assinger and Zellner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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COVID-19-dependent course of the abundance of ANXA5, TALDO1 and EIF4A1 in platelets. Scatter dot plot and time course of ANXA5, TALDO1, and EIF4A1 standardized platelet protein spot abundance in COVID-19 patients quantified by 2D-DIGE (healthy controls: n = 12; COVID-19 survivors: n = 9; COVID-19 non-survivors: n = 4) and their correlation with nasopharyngeal virus load. (A) Protein levels of ANXA5 (spot 2288) and (B) scatter dot plot correlation analysis (Pearson's Rank correlation coefficient) of virus load and 2D-DIGE ANXA5 levels. (C) Protein levels of TALDO1 (spot 2160) and (D) scatter dot plot correlation analysis (Spearman's Rank correlation coefficient) of virus load and 2D-DIGE TALDO1 levels. (E) Protein levels of EIF4A1 (spot 1753) and (F) scatter dot plot correlation analysis (Spearman's Rank correlation coefficient) of virus load and 2D-DIGE EIF4A1 levels. 2D-DIGE, two-dimensional differential in-gel electrophoresis.