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A proposed model for TDRD7 function during autophagy. TDRD7 mediates the maturation of autophagosomes by downregulating the expression of TBC1D20, a process required for the fusion of autophagosomes with lysosomes to form autolysosomes. tdrd7 deletion suppressed the autophagic flux by inhibiting the fusion of autophagosomes with lysosomes and accumulation of ubiquitinated autophagic cargo
