Figure 7.

TNEA treatment promoted the dephosphorylation and nuclear translocation of TFEB in 5XFAD mice brains. (A, B) Representative western blots and quantification showed the levels of the cytosolic (Cyt) and nuclear (Nuc) TFEB in the prefrontal cortex (PFC) and hippocampus (HI) of mice brains. GAPDH and H3F3A were used as cytosolic and nuclear loading controls respectively. Data were quantified as mean ± SEM (male, n = 6). *p < 0.05, vs. 5XFAD group analyzed by Unpaired t test. Another batch of blots was shown in Figure S2. (C) Representative western blots and quantification showed the levels of phosphorylated (p-) TFEB (S142) in the PFC and HI of mice brains. Data were quantified as mean ± SEM (male, n = 6). **p < 0.01 and ***p < 0.001 vs. 5XFAD group analyzed by unpaired t test