Figure 4.

A. muciniphila’s cross-talk with ketogenesis, lipid metabolism and glycolysis related metabolites. (a) Spearman’s rank correlation matrix of A. muciniphila and plasma metabolites belonging to ketone bodies metabolism, TCA cycle, and lipid metabolism, expressed as differential value (delta) (*P < .05). (b) Correlation Network map illustrating the Spearman’s correlation matrix. Metabolites that were highly correlated are brought together. The positioning of the metabolites was calculated by multidimensional scaling of the absolute values of the correlations. Gradient color, distance, and thickness of the lines were applied to metabolites nodes depending on coefficients of correlation. Negative and positives correlations are colored in shades of red and blue, respectively. Abbreviations: Akk, A. muciniphila; BHB, 3-hydroxybutyrate; NEFA, non-esterified fatty acids; X3.HHC, 3-hydroxhexanoylcarnitine