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. 2021 Nov 23;13(1):1996848. doi: 10.1080/19490976.2021.1996848

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© 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Human SOD1^G93A protein was aggregated, and GFAP protein was increased during ALS progression. Aggregation of human-SOD1^G93A protein was observed in the lumbar spine white matter (a) and gray matter (b) starting in 2-month-old SOD1^G93A mice in immunofluorescence staining, immunohistochemistry staining and human-SOD1 protein aggregates percentage analysis. Images are from a single experiment, representative of 6 mice per group. (Data are expressed as mean ± SD. n = 6, one-way ANOVA test, *P < .05, **P < .01, ***P < .001). GFAP expression was enhanced starting from 2-month-old in the lumbar spine white matter (c) and gray matter (d) in the SOD1^G93A mice in immunofluorescence staining, immunohistochemistry staining and GFAP staining quantification. Images are from a single experiment, representative of 6 mice per group. (Data are expressed as mean ± SD. n = 6, one-way ANOVA test, *P < .05, **P < .01, ***P < .001)