Figure 4.
Association of altered ENS and increased aggregation of human-SOD1G93A in the SOD1G93A mice in longitudinal studies. (a) The correlation analysis between intestinal mobility (Whole gut transit time) and latency to fall, forelimb grip strength; staining intensity of GFAP, aggregation of human SOD1G93A protein respectively in the 2-month-old SOD1G93A, compared with WT mice. (P values are labeled in figures, n = 6). Slow Intestinal mobility links with decreased forelimb grip strength, increased staining intensity of GFAP, increased aggregation of human SOD1G93A protein respectively in 2-month-old SOD1G93A. (b) The correlation analysis between aggregation of human SOD1G93A protein and latency to fall and staining intensity of SMMHC in 2-month-old SOD1G93A, compared with WT mice. (P values are labeled in figures, n = 6). Increased aggregation of human SOD1G93A protein links with decreased muscle strength and decreased SMMHC in the 2-month-old SOD1G93A. (c) The correlation analysis between staining intensity of SMMHC and staining intensity of GFAP, staining intensity of PGP9.5 protein respectively in the 2-month-old SOD1G93A, compared with WT mice. (P values are labeled in figures, n = 6). Decreased staining intensity of SMMHC links with increased staining intensity of GFAP and PGP9.5 respectively in the 2-month-old SOD1G93A, compared with WT mice