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. 2021 Nov 23;2021:3928323. doi: 10.1155/2021/3928323

Figure 2.

Figure 2

The cytokine and chemokine expressions are increased in both human nonalcoholic steatohepatitis (NASH) and mouse models of nonalcoholic fatty liver disease (NAFLD). Ingenuity Pathway Analysis results showed that 53 cytokines and chemokines were sorted out from 1376 innate immune genes (innatome, from the Innate Immune Database (https://www.innatedb.com/); also, see our paper (PMID: 33628851)) and 123 cytokines and chemokines were sorted out from 2641 canonical secretome (with signal peptide) genes (from the Human Protein Atlas database (https://www.proteinatlas.org/); also, see our paper (PMID: 32179051)). (a) A schematic figure showed the pathogenic effects of cytokines released from NASH on different organs. Two human NASH datasets (GSE63067 and GSE17470) and four mouse models of NAFLD datasets (GSE35961, GSE63027, GSE63027, and GSE53381) were analyzed. (b, c) The 53 innatome cytokines and chemokines were analyzed in human NASH and mouse models of NAFLD. (d) Venn diagram showed the significant overlapped regulated innatome cytokines and chemokines in human NASH and mouse models of NAFLD. The cytokine and chemokine expressions are increased in both human nonalcoholic steatohepatitis (NASH) and mouse models of nonalcoholic fatty liver disease (NAFLD). (e, f) The 123 canonical secretomic cytokines and chemokines were analyzed in human NASH and mouse models of NAFLD. (g) Venn diagram showed the overlapped significant regulated canonical secretomic cytokines and chemokines in human NASH and mouse models of NAFLD. The cytokine and chemokine expressions are increased in both human nonalcoholic steatohepatitis (NASH) and mouse models of nonalcoholic fatty liver disease (NAFLD). (h) The 16 cytokines and chemokines (innatome and secretome) were upregulated (upregulated in GSE63067 or GSE17470) in human NASH. PMID: 34084175. (i) The 16 cytokines and chemokines (innatome and secretome) were upregulated (GSE35961 or GSE63027) in mouse models of NAFLD. Secretome gene list detailed in our previous publication PMID: 34084175.