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. 2021 Nov 23;2021:3928323. doi: 10.1155/2021/3928323

(a).

Human Mouse
GEO ID GSE17470 GSE63067 GSE35961 GSE63027 GSE63027 GSE53381
Comparison NASH vs. healthy NASH vs. healthy MCD+HFD GNMT-KO MAT1A-KO HFCD
Pathways
 Serotonin degradation
 Ethanol degradation II
 Synaptic long-term depression
 Noradrenaline and adrenaline degradation
 Sperm motility
 Phospholipases
 LXR/RXR activation
 Fatty acid β-oxidation I
 Nicotine degradation II
 eNOS signaling
 Leukocyte extravasation signaling
 p70S6K signaling
 Retinol biosynthesis
 Stearate biosynthesis I (animals)
 Histamine degradation
 Aldosterone signaling in epithelial cells
 HIPPO signaling
 cAMP-mediated signaling
 Synaptic long-term potentiation
 Fcγ receptor-mediated phagocytosis in macrophages and monocytes
 IL-8 signaling
 Rac signaling
 NF-κB activation by viruses
 Salvage pathways of pyrimidine ribonucleotides
 Gαq signaling
 Pyridoxal 5′-phosphate salvage pathway
 GP6 signaling pathway
 Colorectal cancer metastasis signaling
 ILK signaling
 Integrin signaling
 mTOR signaling
 Phospholipase C signaling
 Cardiac hypertrophy signaling (enhanced)
 ERK5 signaling
 Sphingosine-1-phosphate signaling
 Small cell lung cancer signaling
 Gα12/13 signaling
 Signaling by rho family GTPases
 Superpathway of cholesterol biosynthesis
 PPAR signaling
 Nicotine degradation III
 Melatonin degradation I
 Superpathway of melatonin degradation
 Xenobiotic metabolism CAR signaling pathway
 Xenobiotic metabolism PXR signaling pathway
 Cholesterol biosynthesis I
 Cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
 Cholesterol biosynthesis III (via desmosterol)