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. 2021 Nov 23;2021:3928323. doi: 10.1155/2021/3928323

(b).

Human Mouse
GEO ID GSE17470 GSE63067 GSE35961 GSE63027 GSE63027 GSE53381
Comparison NASH vs. healthy NASH vs. healthy MCD+HFD vs. NCD GNMT-KO vs. WT MAT1A-KO vs. WT HFCD vs. NCD
Pathways
 Superpathway of geranylgeranyl diphosphate biosynthesis I (via mevalonate)
 Estrogen biosynthesis
 Acetone degradation I (to methylglyoxal)
 Mevalonate pathway I
 Tryptophan degradation III (eukaryotic)
 Antioxidant action of vitamin C
 Oxidative phosphorylation
 Glutaryl-CoA degradation
 Valine degradation I
 Isoleucine degradation I
 RhoA signaling
 Mitotic roles of polo-like kinase
 Triacylglycerol biosynthesis
 TCA cycle II (eukaryotic)
 Role of CHK proteins in cell cycle checkpoint control
 Sumoylation pathway
 Apelin adipocyte signaling pathway
 Glutathione-mediated detoxification
 Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate
 CMP-N-acetylneuraminate biosynthesis I (eukaryotes)
 EIF2 signaling
 tRNA charging
 Folate transformations I
 Endocannabinoid cancer inhibition pathway
 Pyrimidine ribonucleotide interconversion
 Pyrimidine ribonucleotide de novo biosynthesis
 NAD salvage pathway II
 PPARα/RXRα activation
 NRF2-mediated oxidative stress response
 Glutathione redox reactions I
 Pancreatic adenocarcinoma signaling
 Estrogen-mediated S-phase entry
 Type II diabetes mellitus signaling
 PCP pathway
 PDGF signaling
 NF-κB signaling
 Neuroinflammation signaling pathway
 Tec kinase signaling
 B cell receptor signaling
 Osteoarthritis pathway
 Th17 activation pathway
 Role of pattern recognition receptors in recognition of bacteria and viruses
 Apelin endothelial signaling pathway
 Cholecystokinin/gastrin-mediated signaling
 T cell exhaustion signaling pathway
 Endothelin-1 signaling
 B cell activating factor signaling
 RANK signaling in osteoclasts
 Toll-like receptor signaling
 Renin-angiotensin signaling