(c).
| Trained immunity | GEO ID | GSE115094 | GSE32515 |
|---|---|---|---|
| Pathways | Comparison | Caspase-11-KO vs. WT | Caspase-1-KO vs. WT |
| Glycolysis | LDHB | 2.520 | |
| PFKFB3 | 1.844 | ||
| ALDOA | 1.883 | ||
| FBP1 | 4.254 | ||
| ALDOA | 1.883 | ||
| ADH7 | 1.624 | ||
| PFKFB1 | 1.511 | ||
| PFKFB2 | 1.606 | ||
| HK1 | -2.535 | ||
| HK2 | -4.554 | ||
| HKDC1 | -1.550 | ||
| PDHA1 | -3.277 | ||
| PFKFB4 | -1.570 | ||
| PFKP | -1.544 | ||
| PGAM1 | -2.484 | ||
| ENO1 | -1.689 | ||
| DLAT | -1.770 | ||
| GALM | -1.700 | ||
| PANK1 | -1.892 | ||
| PFKL | -4.133 | ||
| PGM2 | -1.663 | ||
| PKLR | -3.863 | -2.354 | |
| ALDH1B1 | -2.881 | ||
| ALDH2 | -2.171 | ||
| ALDH3A2 | -1.840 | ||
| DLAT | -1.770 | ||
| ACSS2 | -1.836 | ||
| ADH4 | -2.019 | ||
| GCK | -3.334 | ||
| SLC2A2 | -1.789 | ||
| ACSS1 | -3.206 | ||
| ALDH1B1 | -2.881 | ||
| ALDH2 | -2.171 | ||
| ALDH3A2 | -1.840 | ||
| Mevalonate | PMVK | 1.699 | |
| IDI1 | -3.248 | ||
| HMGCS1 | -1.818 | ||
| HMGCR | -1.894 | ||
| ACAT1 | -1.917 | ||
| IDI1 | -3.248 | ||
| Acetyl-CoA generation | GOT1 | -1.684 | 1.701 |
| BDH1 | -1.964 | ||
| ACO1 | -1.601 | ||
| ACLY | -2.203 | -2.33 | |
| % up | 6/68 (8.8%) | 4/68 (5.9%) | |
| % down | 31/68 (45.6%) | 6/68 (8.8%) |