Table 4.
Estimated proportion of chronic liver disease etiologies and heterogeneity of the estimates in Ethiopia, 2021.
| Etiologies of CLD | No. of studies | Sample size | Frequency | Pooled estimate [95% CI] | Q | I 2 | p-value |
|---|---|---|---|---|---|---|---|
| Infectious etiology | |||||||
| Hepatitis B virus | 11 | 2245 | 955 | 40.0 [29.0,51.0] | 270.9 | 96.3 | <0.001 |
| Hepatitis C virus | 11 | 2107 | 346 | 15.0 [9.0, 21.0] | 240.4 | 95.8 | <0.001 |
| Schistosomiasis | 3 | 127 | 50 | 4.0 [1.0, 6.0] | 2.02 | 1.1 | 0.36 |
| HIV | 2 | 267 | 14 | 5.0 [−2.0, 13] | 6.38 | 84.3 | 0.01 |
| Co-HBV and HCV | 4 | 570 | 8 | 1.0 [0.0, 2.0] | 3.7 | 18.9 | 0.30 |
|
| |||||||
| Noninfectious etiology | |||||||
| Alcohol | 7 | 1412 | 214 | 17.0 [9.0, 25.0] | 184.6 | 96.7 | <0.001 |
| NAFLD | 2 | 931 | 167 | 12.0 [4.0, 28.0] | 51.6 | 98.0 | <0.001 |
| Wilson's disease | 2 | 143 | 2 | 1.0 [−1.0, 3.0] | 0.6 | 0.00 | 0.44 |
| AIH | 2 | 269 | 3 | 1.0 [−0.0, 2.0] | 0.1 | 0.00 | 0.75 |
| Unidentified | 5 | 506 | 214 | 45.0 [34.0, 56.0] | 32.08 | 87.53 | <0.001 |
CLD: chronic liver disease, HBV: hepatitis B virus, HDV: hepatitis D virus, NAFLD: nonalcoholic fatty liver disease, AIH: autoimmune hepatitis, I2: heterogeneity, Q: Cochran's Q.