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. 2021 Nov 11;12:759172. doi: 10.3389/fphar.2021.759172

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Copyright © 2021 Wang, Yang, Liu, Xun, Zhuo, Zhang, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HT combined with PLB therapy reshapes the immune microenvironment of pancreatic cancer in mice. The mice with orthotopic pancreatic tumor received HT combined with PLB (HT 200 mg/kg, PLB 1 mg/kg) and normal saline intraperitoneal treatment for 10 days. Representative tumors in vivo (A), and the tumor weight was compared (n = 4 in each group) (B) (*p < 0.05, **p < 0.01). Tumor tissues infiltrating-MDSCs (n = 3 in each group) (C,D), CD4⁺ (n = 4 in each group) and CD8⁺ T cells (n = 3 in each group) (E,F), M1 macrophages (n = 3 in each group) (G,H) in the control group and the combination therapy group were analyzed and compared (*p < 0.05, **p < 0.01).