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Percentage change in distance traveled. The level of nicotine sensitization was determined by calculating the percentage change in distance traveled from the preinjection phase to the first 30 min of the postinjection phase across each of the initial 15 sessions and on the challenge day for each rat. No group differences were observed but a significant effect of day across the 15 sessions indicates that all groups became sensitized to nicotine. Data is shown as group mean ± SEM.
