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. 2021 Nov 11;12:773241. doi: 10.3389/fphar.2021.773241

TABLE 2.

Comparison of clinical symptom scores.

Drug group (n = 181) Control group (n = 186)
Baseline a 3 months later P-value D-value b Baseline 3 months later P-value D-value b P-value c
Cough 6.18 ± 2.00 3.03 ± 1.64 d <0.001 3.15 ± 1.88 6.06 ± 1.84 3.76 ± 1.70 <0.001 2.31 ± 1.70 <0.001
Expectoration 7.36 ± 2.35 4.57 ± 2.89 d <0.001 2.78 ± 2.53 7.21 ± 2.28 6.05 ± 2.85 <0.001 1.16 ± 2.23 <0.001
Expectoration volume 5.20 ± 2.40 2.62 ± 2.17 d <0.001 2.59 ± 2.04 5.44 ± 2.46 3.10 ± 2.18 <0.001 2.33 ± 1.95 0.251
Total cough score 18.75 ± 5.67 10.23 ± 5.77 d <0.001 8.52 ± 4.71 18.71 ± 5.35 12.90 ± 5.44 <0.001 5.81 ± 4.09 <0.001
Dyspnea 2.32 ± 2.34 1.03 ± 1.56 <0.001 1.29 ± 2.08 2.19 ± 2.19 1.26 ± 1.70 <0.001 0.94 ± 1.71 0.180
Hemoptysis 1.11 ± 2.00 0.36 ± 1.17 <0.001 0.75 ± 2.10 1.39 ± 1.98 0.47 ± 1.22 <0.001 0.92 ± 1.87 0.191
Chest pain 0.60 ± 1.43 0.23 ± 0.92 0.003 0.36 ± 1.17 0.77 ± 1.52 0.26 ± 0.95 <0.001 0.52 ± 1.47 0.131
Total symptom score 22.77 ± 7.06 11.85 ± 7.05 d <0.001 10.92 ± 5.89 23.06 ± 6.11 14.89 ± 6.35 <0.001 8.18 ± 4.77 <0.001

Data are presented as mean ± SD except as otherwise noted.

a

There were no statistical differences in all the clinical symptom scores between the two groups during exacerbation (p > 0.05).

b

D-value, difference value, the difference between baseline and 3 months later.

c

The p-value of the d-value between two groups.

d

There were statistical differences between the two groups 3 months later (p < 0.05).