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. 2021 Nov 11;12:761795. doi: 10.3389/fimmu.2021.761795

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Copyright © 2021 Passos, Koh, Magalhães, Nunes, Gollob and Dutra

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cluster heatmap analysis of activation marker (CD69) and cytokine expression (IFN-γ and IL-10) in DN T-cell subpopulations from indeterminate (IND) and cardiac (CARD) Chagas patients. (A) Top panels contain the cluster heatmap analysis of non-stimulated cultures (MED) and bottom panels contain the cluster heatmap analysis after in vitro stimulation with live parasite (TRP). The left panels show the distribution of TCR αβ DN T cells, and the right panels the TCR γδ DN T cells. (B) Difusion maps showing the trajectories and relationships of the different DN T-cell subpopulations. The top plots contain all patients grouped together and the bottom plots discriminate IND and CARD, showing distinct trajectories progressing toward EM and CM, respectively.