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. 2021 Nov 11;12:763323. doi: 10.3389/fimmu.2021.763323

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Copyright © 2021 Honarmand Tamizkar, Gorji, Gholipour, Hussen, Mazdeh, Eslami, Taheri and Ghafouri-Fard

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Log2 Fold Change Heat Map. A heat map for the subjects with Parkinson diseases and healthy control. Log2 fold change was calculated based on delta Ct value compared to the control samples. Red color implies increased expression while green implies decreased expression. LncRNAs on the right are clustered using a hierarchical clustering method (Ward’s method, Euclidean distances) and 5 clusters were found. Cluster 1 = HULC and PVT1; Cluster 2 = SPRY4-IT; Cluster 3 = LINC-ROR; Cluster 4 = DSCAM-AS1; Cluster 5 = MEG3. Most of patient samples (A1-A50) were located on the left side with increased expression of lncRNAs studied in this work.