| Endovascular treatment compared to standard medical care for wake‐up stroke |
|
Patient or population: people with stroke upon awakening
Setting: hospital emergency department
Intervention: endovascular treatment
Comparison: standard medical care |
| Outcomes |
Anticipated absolute effects* (95% CI) |
Relative effect
(95% CI) |
No. of participants
(studies) |
Certainty of the evidence
(GRADE) |
Comments |
| Risk with standard medical care |
Risk with endovascular treatment |
| Independent functional outcome at end of follow‐up assessed with: mRS 0 to 2 at follow‐up: 90 days |
116 per 1000 |
594 per 1000
(298 to 1000) |
RR 5.12
(2.57 to 10.17) |
205
(2 RCTs) |
⊕⊕⊕⊕
HIGH**
|
|
| Intracranial haemorrhage at follow‐up: mean 90 |
‐ |
‐ |
‐ |
‐ |
‐ |
Data not available from the studies. |
| Death at follow‐up: mean 90 |
326 per 1000 |
222 per 1000
(140 to 349) |
RR 0.68
(0.43 to 1.07) |
205
(2 RCTs) |
⊕⊕⊕⊕
HIGH**
|
|
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
**None of these RCTs could be blinded for investigators or participants due to the nature of the intervention.
CI: confidence interval;mRS: modified Rankin Scale; RCT: randomised controlled trial; RR: risk ratio |
|
GRADE Working Group grades of evidence
High certainty: We are very confident that the true effect lies close to that of the estimate of the effect
Moderate certainty: We are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.
Low certainty: Our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect.
Very low certainty: We have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect. |
