Comparison 4. Subgroup analyses for good functional outcome after intravenous thrombolytic treatment.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
4.1 Age	4	754	Risk Ratio (M‐H, Fixed, 95% CI)	1.13 [1.02, 1.26]
4.1.1 Young age (<= 60 years old)	4	169	Risk Ratio (M‐H, Fixed, 95% CI)	1.08 [0.93, 1.25]
4.1.2 Old age (> 60 years old)	4	585	Risk Ratio (M‐H, Fixed, 95% CI)	1.15 [1.01, 1.32]
4.2 Sex	4	754	Risk Ratio (M‐H, Fixed, 95% CI)	1.10 [0.98, 1.23]
4.2.1 Women	4	338	Risk Ratio (M‐H, Fixed, 95% CI)	1.07 [0.89, 1.30]
4.2.2 Men	4	416	Risk Ratio (M‐H, Fixed, 95% CI)	1.11 [0.96, 1.29]
4.3 NIHSS score	4	754	Risk Ratio (M‐H, Fixed, 95% CI)	1.12 [1.01, 1.23]
4.3.1 Low NIHSS (<= 10)	4	530	Risk Ratio (M‐H, Fixed, 95% CI)	1.08 [0.99, 1.19]
4.3.2 High NIHSS (> 10)	4	224	Risk Ratio (M‐H, Fixed, 95% CI)	1.38 [0.88, 2.16]
4.4 Findings on imaging	3	672	Risk Ratio (M‐H, Fixed, 95% CI)	1.15 [1.04, 1.28]
4.4.1 Large vessel occlusion present	3	213	Risk Ratio (M‐H, Fixed, 95% CI)	1.31 [0.93, 1.85]
4.4.2 Large vessel occlusion absent	3	459	Risk Ratio (M‐H, Fixed, 95% CI)	1.12 [1.01, 1.24]
4.5 Time from first observation of symptoms to onset of treatment	3	600	Risk Ratio (M‐H, Fixed, 95% CI)	1.09 [0.98, 1.22]
4.5.1 <= 3 hours	3	250	Risk Ratio (M‐H, Fixed, 95% CI)	1.06 [0.90, 1.24]
4.5.2 > 3 hours	3	350	Risk Ratio (M‐H, Fixed, 95% CI)	1.12 [0.96, 1.32]