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. 2021 Dec 1;2021(12):CD013776. doi: 10.1002/14651858.CD013776.pub2

2. Participants in the included studies.

Study name Intervention(s) and comparator(s) Screened/eligible (N) Randomized (N) Analyzed (N): efficacy Analyzed (N): safety Finishing trial (N)
Babjuk 2005 Intervention: 
1 g 5‐ALA + BL‐TURBT		 128/122 64 60 NA 60 
Comparator: WL‐TURBT 64 62 NA 62
Drăgoescu 2017  Intervention: 
0.85 g 5‐ALA + BL‐TURBT		 113/113 57  57  NA  57
Comparator: WL‐TURBT 56 56  NA  56
Filbeck 2002 Intervention: 
1 g 5‐ALA + BL‐TURBT		 301/191 151 88 NA 88
Comparator: WL‐TURBT 150 103 NA 103
Geavlete 2010 Intervention: 
HAL + BL‐TURBT		 NA/446 223 176 NA NA
Comparator: WL‐TURBT 233 159 NA NA
Geavlete 2012 Intervention: 
HAL + BL‐TURBT		 362/269 181 125  NA 48
Comparator: WL‐TURBT 181 114  NA 37
Gkritsios 2014 Intervention: 
0.85 g 5‐ALA + BL‐TURBT 		 130/104  66 48  NA 48
Comparator: WL‐TURBT  64 37 NA 37
Hermann 2011 Intervention: 
0.85 g 5‐ALA + BL‐TURBT		 223/223 115 68 NA  68
Comparator: WL‐TURBT  118 77  NA 77
Karaolides 2012 Intervention: 
HAL + BL‐TURBT		 102/102 49 41 NA 41
Comparator: WL‐TURBT 53  45 NA 45
Kriegmaier 2002 Intervention: 
1 g 5‐ALA + BL‐TURBT 		 165/129 83 65 NA 65 
Comparator: WL‐TURBT  82 64 NA 64
Neuzillet 2014 Intervention: 
0.85 g 5‐ALA + BL‐TURBT 		 151/151 72  72  NA 43
Comparator: WL‐TURBT  79 79  NA 50
O’Brien 2013 Intervention: 
HAL + BL‐TURBT		 249/185 129 86 NA 63 
Comparator: WL‐TURBT 120 82  NA 67
Riedl 2001 Intervention: 
1 g 5‐ALA + BL‐TURBT		 115/102 NA 51  51 NA
Comparator: WL‐TURBT NA 51 51 NA
Rolevich 2017 Intervention: 
1 g 5‐ALA + BL‐TURBT 		 525/377 252 174  NA  NA
Comparator: WL‐TURBT 273  203  NA  NA
Schumacher 2010 Intervention: 
1 g 5‐ALA + BL‐TURBT 		 300/279  153 141 NA  136
Comparator: WL‐TURBT 147 138 NA 134 
Stenzl 2010 Intervention: 
0.85 g 5‐ALA + BL‐TURBT		 814/766 382  200  421 200
Comparator: WL‐TURBT 384 202 391 202
Stenzl 2011 Intervention: 
1 g 5‐ALA + BL‐TURBT  		 381/370
  192 183 187 NA
Comparator: WL‐TURBT 
  189 176 183 NA
Intervention total
  2169 1635 659 994
Comparator total
  2183 1648 625 1011
Grand total
  4352 3283 1284 2005

5‐ALA: 5‐aminolevulinic acid

BL‐TURBT: blue light transurethral resection of bladder tumor

HAL: hexaminolevulinic acid

NA: not available

WL‐TURBT: white light transurethral resection of bladder tumor