Tandogdu 2019.

Study name	PHOTOdynamic versus white light‐guided treatment of non‐muscle invasive bladder cancer: randomised trial of clinical and cost‐effectiveness
Methods	randomized multicenter
Participants	Estimated enrollment 533 participants Study setting primary only intermediate/high risk Eligibility criteria visual/ultrasound/CT diagnosis of intermediate‐/high‐risk NMIBC white light visual appearances of intermediate‐ or high‐risk disease (3‐centimeter tumor size, 2 or more tumors, or flat velvety erythematous changes alerting a clinical suspicion of CIS) suspicion of papillary bladder tumour > 3 cm based on ultrasound or CT scanning (without hydronephrosis) Non‐eligibility criteria visual evidence of low‐risk NMIBC (solitary tumor < 3 cm) visual evidence of MIBC on preliminary cystoscopy, i.e. non‐papillary or sessile mass (attached directly by its base without a stalk) upper tract (kidney or ureteric) tumors on imaging any other malignancy in the past 2 years (except non‐melanomatous skin cancer cured by excision, adequately treated CIS of the cervix, ductal/lobular CIS of the breast, or prostate cancer in patients who have a life expectancy of > 5 years upon trial entry) evidence of metastases porphyria or known hypersensitivity to porphyrins
Interventions	Intervention: blue light TURBT Control: white light TURBT
Outcomes	Primary outcomes bladder cancer recurrence at 3 years analysis of cost‐effectiveness Secondary outcomes progression rate at 3 years safety health‐related quality of life cancer‐specific survival
Starting date	September 2014
Contact information	Date of contact attempt to first study author: 28 July 2021 Contact status: reply by author 28 July 2021; manuscript is currently being prepared
Notes	www.isrctn.com/ISRCTN84013636

CIS: carcinoma in situ

CT: computerized tomography 

MIBC: muscle invasive bladder cancer

NMIBC: non‐muscle invasive bladder cancer

PUNLMP: papillary urothelial neoplasm of low malignant potential

TURBT: transurethral resection of bladder tumor

WHO: World Health Organization