Table 4.
A Multivariate analysis for non-relapse mortality. B Multivariate analysis for relapse incidence. C Multivariate analysis for event-free survival. D Multivariate analysis for overall survival.
| Ruxolitinib pretreated yes vs. no | Ruxolitinib split according to the response | ||||
|---|---|---|---|---|---|
| Factor | HR (95% CI) | p value | Factor | HR (95% CI) | p value |
| RUX vs. No RUX | 0.80 (0.51–1.25) | 0.323 | Ongoing vs. no/lost spleen response | 0.56 (0.30–1.04) | 0.069 |
| Age: ≥58 vs. <58 | 1.40 (0.95–2.04) | 0.086 | Ongoing spleen response vs. No RUX | 0.66 (0.36–1.20) | 0.172 |
| DIPSS: High vs. Other | 1.13 (0.66–1.96) | 0.651 | No/lost response vs. No RUX | 1.17 (0.62–2.20) | 0.626 |
| DIPSS: Missing vs. Other | 1.19 (0.70–2.03) | 0.525 | Age: ≥58 vs <58 | 1.46 (0.97–2.21) | 0.071 |
| Unrelated vs. matched donor | 1.73 (1.08–2.76) | 0.023 | DIPSS: High vs Other | 1.08 (0.61–1.92) | 0.781 |
| Mismatched vs. matched donor | 3.43 (1.86–6.32) | <0.01 | DIPSS: Missing vs. Other | 1.52 (0.85–2.72) | 0.160 |
| Unrelated vs. matched donor | 1.55 (0.95–2.52) | 0.077 | |||
| Mismatched vs. matched donor | 2.79 (1.45–5.36) | 0.002 | |||
| RUX vs. No RUX | 0.68 (0.41–1.11) | 0.121 | Ongoing vs. no/lost spleen response | 0.41 (0.15–1.09) | 0.073 |
| Age: ≥58 vs. <58 | 1.23 (0.83–1.83) | 0.300 | Ongoing spleen response vs. No RUX | 0.34 (0.12–0.95) | 0.039 |
| DIPSS: High vs. Other | 1.08 (0.73–1.58) | 0.713 | No/lost response vs. No RUX | 0.83 (0.51–1.34) | 0.449 |
| DIPSS: Missing vs. Other | 0.67 (0.40–1.12) | 0.128 | Age: ≥58 vs. <58 | 1.34 (0.91–1.96) | 0.133 |
| Unrelated vs. matched donor | 0.80 (0.44–1.46) | 0.467 | DIPSS: High vs. Other | 1.06 (0.66–1.70) | 0.809 |
| Mismatched vs. matched donor | 0.65 (0.20–2.13) | 0.474 | DIPSS: Missing vs. Other | 0.71 (0.38–1.31) | 0.273 |
| Unrelated vs. matched donor | 0.84 (0.42–1.66) | 0.615 | |||
| Mismatched vs. matched donor | 0.62 (0.16–2.44) | 0.495 | |||
| RUX vs. No RUX | 0.81 (0.59–1.11) | 0.196 | Ongoing vs. no/lost spleen response | 0.55 (0.37–0.81) | 0.003 |
| Age: ≥58 vs. <58 | 1.41 (1.10–1.80) | 0.007 | Ongoing spleen response vs. No RUX | 0.61 (0.40–0.91) | 0.016 |
| DIPSS: High vs. Other | 1.07 (0.74–1.53) | 0.727 | No/lost response vs. No RUX | 1.11 (0.69–1.77) | 0.676 |
| DIPSS: Missing vs. Other | 0.95 (0.69–1.29) | 0.725 | Age: ≥58 vs. <58 | 1.48 (1.12–1.97) | 0.006 |
| Unrelated vs. matched donor | 1.18 (0.79–1.74) | 0.422 | DIPSS: High vs. Other | 1.00 (0.70–1.44) | 0.982 |
| Mismatched vs. matched donor | 1.94 (1.12–1.80) | 0.017 | DIPSS: Missing vs. Other | 1.08 (0.79–1.47) | 0.635 |
| Interval Diagnosis-Transplant: +1 month | 1.00 (1.00–1.00) | 0.903 | Unrelated vs. matched donor | 1.16 (0.76–1.77) | 0.493 |
| Mismatched vs. matched donor | 1.87 (1.06–3.28) | 0.030 | |||
| Interval Diagnosis-Transplant: +1 month | 1.00 (1.00–1.00) | 0.983 | |||
| Ruxolitinib vs. No Ruxo | 0.81 (0.59–1.13) | 0.215 | Ongoing vs. no/lost spleen response | 0.69 (0.42–1.11) | 0.123 |
| Age: ≥58 vs. <58 | 1.37 (1.05–1.78) | 0.021 | Ongoing spleen response vs. No Ruxo | 0.76 (0.50–1.17) | 0.212 |
| DIPSS: High vs. Other | 1.19 (0.80–1.79) | 0.391 | No/lost response vs. No Ruxo | 1.11 (0.67–1.85) | 0.688 |
| DIPSS: Missing vs. Other | 1.10 (0.74–1.65) | 0.629 | Age: ≥58 vs. <58 | 1.42 (1.04–1.95) | 0.026 |
| Unrelated vs. matched donor | 1.47 (1.02–2.12) | 0.039 | DIPSS: High vs. Other | 1.16 (0.77–1.74) | 0.485 |
| Mismatched vs. matched donor | 2.46 (1.45–4.19) | 0.001 | DIPSS: Missing vs. Other | 1.27 (0.87–1.86) | 0.216 |
| Interval Diagnosis-Transplant: +1 month | 1.00 (1.00–1.00) | 0.536 | Unrelated vs. matched donor | 1.35 (0.92–2.00) | 0.128 |
| Mismatched vs. matched donor | 2.37 (1.40–4.03) | 0.001 | |||
| Interval Diagnosis-Transplant: +1 month | 1.00 (1.00–1.00) | 0.464 | |||