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. 2021 Nov 11;12:746300. doi: 10.3389/fphys.2021.746300

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Copyright © 2021 Kutumova, Kiselev, Sharipov, Lifshits and Kolpakov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Modular agent-based physiological model of the cardiovascular and renal systems. (A) An example of the “Pulmonary arteries” module representation. (B) The model implemented in the BioUML platform is divided into nine modules responsible for the kidney function (green) and 11 modules that simulate dynamics of the cardiovascular system (purple). Blue arrows indicate directed connections between the renal and cardiovascular sub-diagrams (Figure 4). For visual simplicity of the diagram, we added transitional nodes (busses) which are used for connections between modules. The busses corresponding to one variable can be located far apart in the diagram. A complete list of equations for each module is given in the Supplementary Appendix Table A2.