Skip to main content
. 2021 Nov 12;8:705796. doi: 10.3389/fmed.2021.705796

Table 1.

Summary of pairwise comparisons between disease groups.

I. CXC chemokines
  A. Neutrophil chemoattractants
• Growth-related oncogene (GRO)-α/CXCL1
BD > VKH, sarcoidosis
HLA-B27 > VKH, sarcoidosis
• GRO-β/CXCL2
BD > VKH
HLA-B27 > VKH, sarcoidosis
• Epithelial-derived neutrophil attractant-78 (ENA-78)/CXCL5
BD > VKH
HLA-B27 > VKH, sarcoidosis
• Granulocyte chemotactic protein-2 (GCP-2)/CXCL6
BD > VKH
HLA-B27 > VKH, sarcoidosis
• Interleukin-8 (IL-8)/CXCL8
BD > VKH
HLA-B27 > VKH, sarcoidosis
  B. T helper-1 (Th1) lymphocyte chemoattractants
Interferon-γ-inducible protein of 10 kDa (IP-10)/CXCL10
BD >VKH
  C. Lymphoid chemokines
B cell attracting chemokine-1 (BCA-1)/CXCL13
VKH, sarcoidosis > BD
VKH > HLA-B27
II. Soluble form of transmembrane chemokines (Preferentially act on Th1 lymphocytes)
• Scavenger receptor for phosphatidyl serine and oxidized low-density lipoprotein
(SR-PSOX)/CXCL16
BD > VKH, sarcoidosis
HLA-B27 > VKH, sarcoidosis
• Fractalkine/CX3CL1
BD > VKH
HLA-B27 > VKH, sarcoidosis
Sarcoidosis > VKH
III. CC chemokines
• Monocyte chemotactic protein (MCP)-1/CCL2
BD > VKH
HLA-B27 > VKH, sarcoidosis
• MCP-3/CCL7
BD > VKH
HLA-B27 > VKH, sarcoidosis
• MCP-2/CCL8
BD, HLA-B27 > sarcoidosis
HLA-B27 > VKH
• MCP-4/CCL13
HLA-B27 > VKH, sarcoidosis
• Thymus- and activation-related chemokine (TARC)/CCL17
HLA-B27 > VKH
• Macrophage inflammatory protein (MIP)-3α/CCL20
BD > VKH
HLA-B27 > BD, VKH, sarcoidosis
• Thymus-expressed chemokine (TECK)/CCL25
HLA-B27 > VKH, sarcoidosis
• Eotaxin-3/CCL26
BD > VKH
HLA-B27 > VKH, sarcoidosis
IV. Cytokines and soluble cytokine receptors
• Interferon-γ
BD > VKH
HLA-B27 > VKH, sarcoidosis
• Tumor necrosis factor-α (TNF-α)
HLA-B27 > VKH
• Interleukin (IL)-1β
BD > VKH
HLA-B27 > BD, VKH, sarcoidosis
• IL-6
BD > VKH, sarcoidosis
HLA-B27 > VKH, sarcoidosis
• IL-11
HLA-B27 > VKH, sarcoidosis
• IL-12p40
BD > VKH
HLA-B27 > VKH
• IL-19
HLA-B27 > BD, VKH, sarcoidosis
• IL-35
HLA-B27 > VKH
• Granulocyte-macrophage colony-stimulating factor (GM-CSF)
HLA-B27 > VKH, sarcoidosis
• The TNF-like weak inducer of apoptosis (TWEAK)
VKH > HLA-B27
Sarcoidosis > BD, HLA-B27
• Soluble (s) CD30
VKH > BD, HLA-B27

BD, Behçet's disease; HLA-B27, HLA-B27-associated uveitis; VKH, Vogt-Koyanagi-Harada disease.