Fig. 5.

Diagram of MIEA. The fitness of all peptides in a population P_n is evaluated by molecular docking. Based on this, a population P_n+1 is newly generated by copying the peptides with the lowest binding energy, with and without crossover recombination of their sequences, and introducing random mutations. Further, a number of X individual peptides with the best binding energy are directly copied into the population P_n+1 without alteration. This population P_n+1 is then again evaluated via docking to complete the MIEA cycle.