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. 2021 Nov 12;13:741168. doi: 10.3389/fnagi.2021.741168

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Copyright © 2021 Wang, Wei, Ho, Wu, Chu and Tsai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Electrical stimulation treatment inhibits neuronal cell death of the brain in the MCAO animal model. (A) Representative pictures of immunofluorescence stains for NeuN (red fluorescence), cleaved caspase-3 (green fluorescence), and DAPI (blue fluorescence). The red blocked box in the top-right panel represents views in the penumbral region. (B) Quantitative analysis for NeuN immunoreactive cells. The ES group shows significantly higher neurons survival than the control group. (C) Quantitative analysis shows a significantly reduced number of immunoreactive cells for cleaved caspase-3 in the ES group, demonstrating the antiapoptotic effect of ES (Sham n = 5; MCAO n = 10; and MCAO + ES n = 10; scale bar = 50 μm). *p < 0.05.