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. 2021 Nov 12;11:651535. doi: 10.3389/fonc.2021.651535

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Copyright © 2021 Zhang, He, Shen, Wang, Liu and Jiang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MiR-489-3p targets LDHA and PKM2. (A, B) qRT-PCR and western blot assays showed relative expression of LDHA and PKM2 after PC cells transfected with miR-489-3p mimics and miR-489-3p inhibitor. (C) Spearman rank correlation analysis showed correlation between miR-489-3p and LDHA and PKM. (D) The predicted binding site of miR-489-3p in human LDHA and PKM gene 3’ UTR, and the corresponding sequence in the mutated type. (E) Luciferase reporter gene assay analysis of the relationship between miR-489-3p and LDHA and PKM. (*P < 0.05, **P < 0.01, ***P < 0.001, ns, no significant).