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. 2021 Nov 12;11:651535. doi: 10.3389/fonc.2021.651535

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Copyright © 2021 Zhang, He, Shen, Wang, Liu and Jiang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LDHA and PKM2 restored the function of miRNA-mediated proliferation and metastasis ability. (A) Western blot experiments showed that the relative expression of LDHA and PKM2 in PC cells transfected with miR-489-3p mimic, inhibitor, LDHA, PKM2 overexpressed plasmid or shRNA. (B, C) CCK8 and plate cloning and transwell migration assays showed that the proliferation ability of PC cells transfected with miR-489-3p mimic, inhibitor, LDHA, PKM2 overexpressed plasmid or shRNA. (D) Transwell assays show that the migration and invasion ability of PC cells transfected with miR-489-3p mimic, inhibitor, LDHA, PKM2 overexpressed plasmid or shRNA. (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).