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MiR-489-3p suppresses glycolysis through LDHA and PKM2. (A–C) Cell metabolism experiments showed that glucose uptake, lactic acid production, and ATP production of PC cells transfected with miR-489-3p mimic, inhibitor, LDHA, PKM2 overexpressed plasmid or shRNA. (D) The hippocampal XF extracellular flux analyzer analysis of the PC ECAR after transfected with miR-489-3p mimic, inhibitor, LDHA, PKM2 overexpressed plasmid or shRNA. (*P < 0.05, **P < 0.01, ***P < 0.001).
