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. 2021 Nov 12;11:651535. doi: 10.3389/fonc.2021.651535

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Copyright © 2021 Zhang, He, Shen, Wang, Liu and Jiang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of overexpression of miR-489-3P on PC proliferation and metabolism in vivo. (A) Typical images of nude mice tumors (n = 5), (B) subcutaneous tumor weight, (C) subcutaneous tumor volume, (D) miR-489-3p expression in xenografts by qRT-PCR. (E) Typical IHC staining images of xenografts show Ki-67 and PCNA expression. The bar stands for 50 microns. (F) Typical IHC staining images of xenografts show the expression of metabolic indicators (LDHA, GLUT1, HK2, PKM2). The bar stands for 100 microns. (**P < 0.01, ***P < 0.001).