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. 2021 Nov 12;11:735180. doi: 10.3389/fonc.2021.735180

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Copyright © 2021 Pu, Zhang, Yan, Li, Liu, Jian, Mahgoub, Gu, Xiong and Zou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MICAL2, TGF-β, and p-Smad2 expresssion levels are elevated in GBM cells. (A) Immunohistochemical results showed that the expression level of MICAL2, TGF-β, and p-Smad2 are elevated in high-grade gliomas. (B) Regression linear equations fitted to the relative expression levels of MICAL2 and p-Smad2 in GBM tissues. (C, D) Kaplan-Meier survival analysis in 81 primary GBM cases stratified by MICAL2 expression level indicates that high level of MICAL2 expression was associated with lower OS (p = 0.011 < 0.05), but there was no significant difference in DFS between low MICAL2 and high MICAL2 expression levels (p = 0.093 > 0.05).